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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Ancell/CD278(ICOS)-muIg/25 g/517-030
产品编号:517-030
市  场 价:¥7500.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$375.00
品      牌: Ancell
公      司:Ancell
公司分类:
Ancell/CD278(ICOS)-muIg/25 g/517-030
商品介绍

The inducible costimulator CD278 (ICOS, T cell activation molecule H4) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Each secondary signal from CD28 or ICOS results in a discrete cytokine secretion profile displayed by the activated T cell.1 Both activation processes are effectively down regulated by CD152 (CTLA-4) engagement.2 Human CD275 (ICOSL, GL50, B7-H2) is a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2), and has been shown to be a ligand for CD278.3 CD278-muIg recombinant protein binds to recombinant CD275-muIg in EIA.

Molecular Structure:A soluble fusion protein consisting of the extracellular (121aa) domain of mature human CD278(ICOS): eingsanyemfifhnggvqilckypdivqqfkmqllkggqilcdltktkgsgntvsikslkfchsqlsnnsvsfflynldhshanyyfcnlsifdpppfkvtltggylhiyesqlccqlkf

linker amino acids: gt

fused to murine IgG2a Fc (233 aa): eprgptikpcppckcpapnllggpsvfifppkikdvlmislspivtcvvvdvseddpdvqiswfvnnvevhtaqtqthredynstlrvvsalpiqhqdwmsgkefkckvnnkdlpapiertiskpkgsvrapqvyvlpppeeemtkkqvtltcmvtdfmpediyvewtnngktelnykntepvldsdgsyfmysklrvekknwvernsyscsvvheglhnhhttksfsrtpgk

predicted nonglycosylated monomeric molecular weight: 40.4 kd.

Transfectant Cell Line: CHO

Functional Application:CD278-muIg binds to recombinant CD275(ICOSL, GL50)-muIg in EIA.

References:

1Beier, K.C., R.A. Kroczek, et al. 2000, Eur J Immunol. 30(12):3707-3717.

2 Riley, J.L., C.H. June, et al. 2001, J. Immunol. 166: 4943-4948.

3 Ling, V., M. Collins, et al. 2000, J. Immunol. 164: 1653-1657.

4 Ling, V., M. Collins, et al. 2001, J. Immunol. 166: 7300-7308.

5 A.J. McAdam, et al, (2000) J Immunol 165: 5035-5040.

品牌介绍

Ancell世界著名的专注做人种属的流试抗体提供商。提供FITC、PE、APC、生物素和纯化human 抗体,可用于流式,FA 实验。并提供融合蛋白。

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