Human CD22 expression is restricted to normal Ig+ mature B cells and neoplastic B cells. CD22 is a transmembrane glycoprotein of 140 kd with a predicted adhesion molecule function.

Isotype: Murine IgG1

Immunogen: Human tonsil lymphocytes

Specificity: Antibody RFB4 recognizes the CD22 molecule of about 140 kd (1, 2, 3).

References:

1. D. Campana, et al, (1985) J Immunol 134: 1524-1530.

2. J.L. Li, et al, (1989) Cell Immunol 118: 85-99.

3. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 190-193.

4. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 523-530.

5. D. Shan & O.W. Press, (1995) J Immunol 154: 4466-4475.

6. S. Behr & F. Schriever, (1995) J Exp Med 182: 1191-1199.

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