Human CD18 (beta integrin) forms a heterodimer with either alpha L, alpha M, or alpha X integrins (CD11a, b or c). CD11/CD18 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses.

Isotype: Murine IgG2a

Immunogen: Human peripheral blood monocytes

Specificity: Antibody IB4 recognizes the beta 2 integrin subunit (CD18) adhesion molecule of about 95 kd (1, 6).

Functional Application: Antibody IB4 blocks binding of ICAM-1 and ICAM-3 to LFA-1 (2, 5).

References:

1. S.D. Wright, et al, (1983) Proc Natl Acad Sci USA 80: 5699-5703.

2. R.C. Landis, et al, (1994) J Cell Biol 126: 529-537.

3. M. Kaneko, et al, (1995) J Immunol 155: 2631-2641.

4. A. Mazzone & G. Ricevuti, (1995) Haematologica 80: 161-175.

5. M.E. Berman, et al, (1996) J Immunol 156: 1515-1524.

6. K Welzenbach, G Weitz-Scmidt, et al (2002) J Biol Chem 277(12): 10590 - 10598. PMID: 11781316

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