Human CD4 is a cell surface glycoprotein of 55 kd expressed on most thymocytes, on about two thirds of peripheral T cells, and on some monocyte macrophage lineage cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The amino terminal region of CD4 is a receptor for the HIV-1 viral protein gp120.

Antibodies QS4120 (cat #147-020) and M-T441 each bind to a distinct epitope of CD4 and are suitable as a matched pair for EIA using QS4120 as capture and Biotinylated M-T441(cat# 148-030) as detector.

Isotype: Murine IgG2b

Immunogen: P815 cells transfected with human CD4

Specificity: Antibody M-T441 recognizes an extracellular epitope within the domain 2 region of the CD4 molecule and reacts with human CD4 cell transfectants (1). It has been reported to cross react with Baboon CD4.

References:

1. Characterized by the laboratory of Dr. E.P. Reiber.

2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 476-478.

3. R. König, et al, (1995) J Exp Med 182: 779-787.

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