Human CD11c (alpha X integrin) complexes with CD18 (beta 2 integrin) to form the complement receptor type 4 (CR4) heterodimer which binds to fibrinogen and is involved with monocyte/granulocyte adhesion during inflammatory responses (2). CD11c expression is restricted to leukocytes mainly of myeloid lineage with highest expression on macrophages.

Isotype: Murine IgG1

Immunogen: Human rheumatoid synovial fluid cells/monocytes

Specificity: Antibody 3.9 recognizes the human integrin alpha X subunit (CD11c) of about 150 kd (1, 4). It is cross reactive with cynomolgus monkey CD11c (5).

References:

1. N. Hogg, et al, (1986) Eur J Immunol 16: 240-248.

2. S.A. Stacker & T.A. Springer, (1991) J Immunol 146: 648-655.

3. M. Patarroyo, (1994) Immunobiology 191: 474-477.

4. Leukocyte Typing V (1995) (S.F. Schlossman, et al., eds.) Oxford University Press, Oxford,p. 1590-1592.

5. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

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