Human CD100 is a transmembrane glycoprotein that belongs to the semaphorin gene family and is found on most hematopoietic cells except RBC, platelets and immature bone marrow cells. CD100 plays a key role in lymphocyte activation (2, 3). Interaction of CD100 with its ligand CD72 has implications in the mechanism of NK cell killing (4).

Isotype: Murine IgM

Immunogen: PHA stimulated human PBL

Specificity: Antibody 133-1C6 recognizes an extracellular epitope of the human CD100 molecule of about 150 kd.

References:

1.) Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 534-539.

2.) K.T. Hall, et al, (1996) Proc Natl Acad Sci USA 93:11780-11785.

3.) A. Elhabazi, et al, (1997) J Biol Chem 272: 23515-23520.

4.) S. Mizrahi, O Mandelboim, et al.(2007) PLoS ONE 2(9):e818.

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