Human tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine expressed mainly by activated monocytes and macrophages. TNF alpha exerts a key role with regard to pathogenesis of many infectious and inflammatory diseases.

Isotype: Murine IgG1

Immunogen: Recombinant human TNF alpha

Functional Application: Antibody J1D9 neutralizes TNF alpha biological activities (2). It prevents TNF alpha induced apoptosis in Jurkat cells (5).

References:

1. P. Vassalli, (1992) Annu Rev Immunol 10: 411-452.

2. P.J. McLaughlin, et al, (1992) Anticancer Res 12: 1243-1246.

3. M. Pasparakis, et al, (1996) Cytokine and Growth Factor Reviews 7: 223-229.

4. A. Eigler, et al, (1997) Immunology Today 18: 487-492.

5. Kalli K R, Kaufmann S H, et al. (2003) Molecular Pharmacology 64(6): 1434-1443.

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