Human CD104 (beta 4 integrin) associates with the alpha 6 integrin chain and binds to laminin and epiligrin and likely has cell-cell adhesion functions. CD104 is involved in signal transduction (4).

Isotype: Murine IgG2a

Immunogen: UM-SCC-1, human squamous cell carcinoma

Specificity: Antibody UMA9 recognizes an extracellular epitope of the CD104 molecule of about 205 kd (1, 3).

Functional Application: Partially blocks laminin binding.

References:

1. K.A. Kimmel & T.E. Carey, (1986) Cancer Res 46: 3614-3623.

2. C VanWaes, et al, (1991) Cancer Res 51: 2395-2402.

3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1655-1663, 1667-1668.

4. F. Mainiero, et al, (1995) EMBO J 14: 4470-4481.

5. S Tyagi, AR Ahmed, et al. (1996) PNAS 93(25): 14714-14719. PMID: 8962120

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