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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Ancell/anti-CD357(GITR)/100 g/268-030
产品编号:268-030
市  场 价:¥5500.00
场      地:美国(厂家直采)
产品分类: 抗体类>二抗>抗生物素>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$275.00
品      牌: Ancell
公      司:Ancell
公司分类:
Ancell/anti-CD357(GITR)/100 g/268-030
商品介绍

Glucocorticoid induced Tumor Necrosis Factor receptor family related gene (GITR, AITR) is a type 1 228 amino acid transmembrane protein that has been designated TNFRSF18. GITR is expressed mainly by CD4+ CD25+ T lymphocytes. Its engagement by antibodies or its ligand (GITRL) induces a costimulatory signal which can break T cell suppression (2). GITR has been implicated as a regulatory mechanism in anti-parasitic immune resposes (4), and is involved with Macrophages activation in atherosclerotic plaque formation (3).

Clone ANC7D6-1E7 binds to human GITR in EIA and on stimulated cell surface in FACS. Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.

Isotype: Murine IgM kappa

Immunogen: Recombinant human GITR, PHA stimulated human PBL

Specificity: Antibody ANC7D6-1E7 binds to human GITR in EIA and on cell surface in FACS. Preincubation of the receptor with an excess of this mAb will block binding of recombinant GITR Ligand.

References:

1) Gurney AL, et al. (1999) Curr Biol 9(4): 215-218.

2) Ji HB, et al. (2004 ) J Immunol 172(10): 5823-5827.

3) Kim WJ, WH Lee, et al. (2006) Immunology 119(3): 44-9.

4) Furze RC, Selkirk ME, et al. (2006) Microbes Infect 8 (12-13): 2803-10.

5) Kohm AP, SD Miller, et al. (2004) J Immunol 172: 4686-4690. .

6) McHugh, R.S. et al. (2002) Immunity 16:311.

7) Shin, H.H. et al. (2002) FEBS Lett. 514:275.

8). Shimizu, J. et al. (2002) Nature Immunol. 3:135.

品牌介绍

Ancell世界著名的专注做人种属的流试抗体提供商。提供FITC、PE、APC、生物素和纯化human 抗体,可用于流式,FA 实验。并提供融合蛋白。

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